Tamás Korcsmáros

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Analyzing interspecies interactions between hosts and microbes is crucial for
understanding how microbiota changes can disrupt host homeostasis and
lead to disease. High-throughput sequencing and omics approaches have
advanced our understanding of these interactions in the gastrointestinal tract.
We developed MicrobioLink, a computational pipeline that predicts host-
microbe protein interactions, integrating multi-omic data with network biology
to enhance insights into these complex interactions, especially in
inflammatory and infectious diseases. Our research focuses on autophagy,
often targeted by microbes. We mapped interactions between human
autophagy proteins and 56 pathogenic bacterial species, identifying bacterial
proteins that modify autophagy components. We are now using organoid and
gut-on-chip systems to validate our computational predictions, moving
beyond traditional cell-line infection assays.

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Imperial College London
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Contact: Viera Kovacova