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I will describe the modeling of several genetic regulatory modules in cells and analyze the effects of competition, feedback and fluctuations in these systems using deterministic and stochastic methods. The genetic networks to be considered involve a combination of transcriptional regulation, regulation by small non-coding RNA's and protein-protein interactions. The effects of competition, feedback and fluctuations on each one of these regulation mechanisms will be discussed. I will present results obtained using a combination of deterministic and stochastic methods, including rate equations, direct integration of the master equation and Monte Carlo simulations.

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Prof. Ofer Biham, Racah Institute of Physics, Hebrew University of Jerusalem
Institute for Genetics, New Seminar Room, Ground Floor
Contact: not specified