None | July 06, 14:45

Competition, feedback and fluctuations in genetic regulatory modules

Prof. Ofer Biham

I will describe the modeling of several genetic regulatory modules
in cells and analyze the effects of competition, feedback and
fluctuations in these systems using deterministic and stochastic
methods. The genetic networks to be considered involve a combination
of transcriptional regulation, regulation by small non-coding RNA's
and protein-protein interactions. The effects of competition, feedback
and fluctuations on each one of these regulation mechanisms will be
discussed. I will present results obtained using a
combination of deterministic and stochastic methods, including
rate equations, direct integration of the master equation and
Monte Carlo simulations.


Racah Institute of Physics, Hebrew University of Jerusalem
Institute for Genetics, New Seminar Room, Ground Floor
Contact: not specified